2020, XXXX, XXX, XXX-XXX DOI: 10.1021/acsnano.0c03697, Opportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19 DOI: 10.1021/acscentsci.9b01093, An Epoxide Intermediate in Glycosidase Catalysis DOI: 10.1021/acs.langmuir.0c01125, Supramolecular Polymer Brushes: Influence of Molecular Weight and Cross-Linking on Linear Viscoelastic Behavior DOI: 10.1021/acs.nanolett.0c00950, Nanobowl-Supported Liposomes Improve Drug Loading and Delivery DOI: 10.1021/acssensors.0c00796, Remembering NJ DOI: 10.1021/acschembio.0c00140, Dual-Activatable Cell Tracker for Controlled and Prolonged Single-Cell Labeling Open Access through ACS AuthorChoice DOI: 10.1021/acsabm.0c00260, Update to Our Reader, Reviewer, and Author Communities—April 2020 We are seeking submissions that represent the most exciting innovations and discoveries in this area. You can look at citations, Altmetric Attention Scores, awards, and more. From this, a correlation between the photophysical properties of fluorophores attached to the protein and the predictability of the corresponding smFRET construct was established. DOI: 10.1021/acs.macromol.0c01412, Carbohydrates as Hard Segments for Sustainable Elastomers: Carbohydrates Direct the Self-Assembly and Mechanical Properties of Fully Bio-Based Block Copolymers Recombinantly expressing glycoproteins in HEK293S (GnT1-) cells results in N-glycans with high-mannose structures that can be processed to leave a single GlcNAc residue. DOI: 10.1021/acsmedchemlett.0c00202, Enhanced Binding of SARS-CoV-2 Spike Protein to Receptor by Distal Polybasic Cleavage Sites Open Access through ACS AuthorChoice DOI: 10.1021/jm901757t, Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells Sci. DOI: 10.1021/acs.macromol.0c00550, Impact of the Solvent Quality on the Local Dynamics of Soft and Swollen Polymer Nanoparticles Functionalized with Polymer Chains DOI: 10.1021/acs.est.0c00070, Probing the Contributions of Interior and Exterior Channels of Nanofillers toward the Enhanced Separation Performance of a Thin-Film Nanocomposite Reverse Osmosis Membrane The Journal Impact 2019-2020 of ACS Chemical Biology is DOI: 10.1021/acs.jcim.0c00116, Discovery of New Hydroxyethylamine Analogs against 3CLpro Protein Target of SARS-CoV-2: Molecular Docking, Molecular Dynamics Simulation, and Structure–Activity Relationship Studies DOI: 10.1021/acs.jpcc.0c04452, Dynamics and Proton Transport in Imidazole-Doped Nanocrystalline Cellulose Revealed by High-Resolution Solid-State Nuclear Magnetic Resonance Spectroscopy We acknowledge that we do not have all the answersnow, but we seek to hear from and listen to our community on how we can improveACS journals to be more diverse and inclusive. Each protomer is composed of three domains with the active site located between the middle and C-terminal domains; R169-E272-E277, constituting the catalytic triad, and E228, involved in Mn(II)-mediated binding of prFMN, were confirmed by site-directed mutagenesis. A multiplexed ABPP assay was developed in which a probe cocktail of FP-BODIPY and MB064 visualized most endocannabinoid serine hydrolases in mouse brain proteomes in a single experiment. Through the creation of fungal gene deletion mutants and heterologous protein expression, we unveiled the critical role of the cytochrome P450 monooxygenase (CYP450) GliC for the stepwise bishydroxylation of the diketopiperazine (DKP) core. Insights from the screen provide a strong foundation for further structural elaboration, to improve potency, which will be enabled by the same synthetic strategy. 2019, 30, 3, 907–919 Open Access Through ACS AuthorChoice The cellular selectivity of 15a for CRBN degradation was confirmed at the proteome level by quantitative mass spectrometry.