Some closed comedones do not form a visible white area and are simply small, raised areas of skin. I have small, sometimes larger CC's on my cheeks, especially my left cheek, I get bumps I can't really squeeze at all, and when I do and am able to get something out, I bleed and get scabs. Benzoyl Peroxide . The primary statistical analyses of interest are (1) the percent change from baseline to Week 12 in the number of inflamed (papules/pustules) lesions and non-inflamed (open and closed comedones) lesions. I also still get a couple deep spots. Benzoyl peroxide is also sebostatic, counteracting the excessive sebum production associated with acne. 18. Previous participation in this study. 2. For the full list of excipients, see section 6.1. 18. Animal studies performed with Epiduo include local tolerance studies and dermal repeat-dose toxicity studies in rat, dog and minipig up to 13 weeks and demonstrated local irritation and a potential for sensitisation, as expected for a combination containing benzoyl peroxide. Male or non-pregnant, non-lactating female, ≥ 12 and ≤ 40 years of age with a clinical diagnosis of acne vulgaris. Noninflammatory lesions (open and closed comedones) noticeably responded between the first and fourth week of treatment. :). Since the air cannot reach the follicle, the material is not oxidized and remains white or has the appearance of being "closed". Instead of popping them or picking at them (which we never recommend no matter what type of acne you have), try the dermatologist-approved tips and products below to help treat and prevent closed comedones. Closed comedone extraction can be effective when performed by a skilled dermatologist, however it is not a permanent solution as comedones may form again. This procedure is usually performed only when other treatments prove ineffective as it can cause pain and discomfort. I have a lot of closed comedones and cystic acne on the chin and cheeks. Significant history or current evidence of chronic infectious disease, system disorder, organ disorder or other medical condition that, in the Investigator's opinion, would place the study participant at undue risk by participation. 7. Routine Help. A sterile sexual partner is not considered an adequate form of birth control. These topical treatments are available as gels, creams, lotions and washes. They’re also known as whiteheads and can occur anywhere on the skin, most commonly on the face, chest, back and shoulders. History of allergy or hypersensitivity to adapalene, retinoids, benzoyl peroxide or history of any drug hypersensitivity or intolerance that, in the Investigator's opinion, would compromise the safety of the patient or the study. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme. A sterile sexual partner is not considered an adequate form of birth control. | San Diego, California, 92108, United States, Site 113 These results are comparable to those obtained in previous clinical PK studies on various Adapalene 0.1% formulations, where systemic exposure to adapalene was consistently low. | Henderson, Nevada, 89052, United States, Site 106 | New Albany, Indiana, 47150, United States, Site 107 (2011). By the end of week 3 the burning sensation really started to kick in and it was beyond itchy after every application for a good hour after. If a reaction suggesting sensitivity to any component of the formula occurs, the use of Epiduo should be discontinued. Adapalene and Benzoyl Peroxide Gel, 0.3%/2.5% w/w, Arm Group Label: