Vitamin D fortification in the United States and Canada: Current status and data needs. Endocrine Connections 2018;7:R294-303. Is the stock market open Thanksgiving day and Black Friday? Both forms raise serum 25(OH)D levels, and they seem to have equivalent ability to cure rickets [4]. A systematic review and meta-analysis of 15 weight-loss intervention studies that used caloric restriction, exercise, or both, but not necessarily vitamin D supplementation or other treatments, found that people who lost weight had significantly greater increases in serum 25(OH)D levels than those who maintained their weight [152]. [. [, Skaaby T, Husemoen LLN, Thuesen BH, Pisinger C, Jorgensen T, Roswall N, et al. Interventions to prevent falls in community-dwelling older adults. Possible explanations for this increase include genetic differences in vitamin D metabolism, dietary preferences, and behaviors that lead to less sun exposure [46,47]. Am J Clin Nutr 2004;80:1697S-705S. 09-E015. This is why I’m cheering for the Novavax underdog, Sweden’s population is losing confidence in the country’s strategy to combat COVID-19. They also help reduce fracture rates in institutionalized older people. JAMA 2017;317:1217-8. For example, a 3-year trial in New Zealand randomized 5,110 adults (mean age 65.9 years) to a single dose of 5,000 mcg (200,000 IU) vitamin D3 followed by 2,500 mcg (100,000 IU) each month or a placebo for a median of 3.3 years [124]. [, Cauley JA, Chlebowski RT, Wactawski-Wende J, Robbins JA, Rodabough RJ, Chen Z, et al. In contrast, the United Kingdom government recommends intakes of 10 mcg (400 IU)/day for its citizens aged 4 years and older [16]. Serum concentration of 25(OH)D is currently the main indicator of vitamin D status. One systematic review and meta-analysis of 11 randomized, controlled trials published through 2018 of vitamin D supplementation alone (10–20 mcg [400–800 IU]/day or more at least every week or as rarely as once a year) for 9 months to 5 years found that the supplements provided no protection from fractures in 34,243 older adults [82]. The FNB committee also noted that serum concentrations greater than 125 nmol/L (50 ng/mL) can be associated with adverse effects [1] (Table 1). (Classical Music) Deutsch: indicating the serial number in the catalogue (1951) of the musical compositions of Schubert made by Otto Deutsch (1883–1967), (of a molecule) having a configuration resembling the dextrorotatory isomer of glyceraldehyde: printed as a small capital, roman character (disting. Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: The Women's Health Initiative. A dose-response analysis found that each 20 nmol/L [8 ng/mL] increase in 25(OH)D was associated with a 9% lower risk of both all-cause and prostate cancer-specific mortality. [, Helzlsouer KJ for the VDPP Steering Committee. [, Mheid IA, Quyyumi AA. - You Can Have It Both Ways, My Dividend Portfolio: October 2020 Update - 94 Holdings, 41 Buys, Diamond Hill Capital's Top 5 3rd-Quarter Buys, Dominion to back global climate disclosure framework, Analyst Provides Guidance for This Canadian Energy Company, RBC Capital’s Outlook for This Canada’s Energy Sector Company, The Retiree's Dividend Portfolio - John's September Update: Volatility Sure Makes It Interesting, Dividend Champion And Contender Highlights: Week Of November 8, Dominion Energy, Inc. (D) CEO Tom Farrell on Q3 2020 Results - Earnings Call Transcript, Dominion: Retrenching For A Renewable Future. Vitamin D supplementation to reduce depression in adults: Meta-analysis of randomized controlled trials. Calcium plus vitamin D supplementation and the risk of postmenopausal weight gain. Researchers have not definitively identified serum concentrations of 25(OH)D associated with deficiency (e.g., rickets), adequacy for bone health, and overall health. However, whether these lower levels in persons with dark skin have significant health consequences is not clear [14]. Dominion Energy, Inc. engages in the provision of electricity and natural gas to homes, businesses, and wholesale customers. [, de Koning EJ, Lips P, Penninx BWJH, Elders PJM, Heijboer AC, den Heijer M, et al. In a cohort of 4,733 men, of which 1,731 had prostate cancer, those with 25(OH)D levels of 45–70 nmol/L (18–28 ng/mL) had a significantly lower risk of the disease than men with either lower or higher values [109]. In fact, 2013–2016 NHANES data showed that 92% of men, more than 97% of women, and 94% of people aged 1 year and older ingested less than the EAR of 10 mcg (400 IU) of vitamin D from food and beverages [41]. Lancet Diabetes-Endocrinol 2014;2:719-29. Identification and systematic appraisal. 2. An analysis of NHANES 2011–2014 data on serum 25(OH)D levels found that most people in the United States aged 1 year and older had sufficient vitamin D intakes according to the FNB thresholds [44].