Sci. ISSN: 0968-0896. Once production of your article has started, you can track the status of your article via Track Your Accepted Article. Tetrahedron Prize for Creativity in Organic Chemistry — 2020 Winner Announced! After postdoctoral research in bioorganic and supramolecular chemistry at Yale University and drug discovery work at Anacor Pharaceuticals (now Pfizer), she joined Shanghai Jiao Tong University where she is now a professor in medicinal chemistry and chemical biology. Once production of your article has started, you can track the status of your article via Track Your Accepted Article. Acad. Z Wang, W Xie, M Zhu & H Zhou Bioorg. The awardee has made many important advances in the areas of heterocyclic chemistry and organic synthesis, especially with respect to the synthesis of natural products. Her principal research interests are: (i) design, synthesis, and mechanistic study of small molecules that selectively modulate the functions of important potential anticancer targets which had no known effective ligands before, such as inhibitors that are selective among the six highly resembled SUMO-specific proteases from the ubiquitin system, (ii) using unique chemotype-focused library, phenotypic screening, and molecular probes to discover anticancer and antiinfective compounds and to identify their intracellular targets. Professor Huchen Zhou received her bachelor degree in chemistry from Fudan University and Ph.D. in bioorganic and bioinorganic chemistry from Princeton University. Design, synthesis, and structure-activity relationship of 7-propanamide benzoxaboroles as potent anticancer agents. Chem. Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors. Bioorganic & Medicinal Chemistry Impact Factor IF 2020|2019|2018 - BioxBio In these studies they made the unusual observation that both enantiomers of the natural product constitute effective DNA alkylating agents, have identified a remarkable source of catalysis for the DNA alkylation reaction, and have defined subtle structural and stereoelectronic features of the agents that contribute to functional reactivity and reaction regioselectivity and their impact on the DNA alkylation and biological properties. brevicompactum and their structure-activity relationship, Antifungal trichothecene sesquiterpenes obtained from the culture broth of marine-derived, select article Discovery of a novel selective water-soluble SMAD3 inhibitor as an antitumor agent, Discovery of a novel selective water-soluble SMAD3 inhibitor as an antitumor agent, select article Synthesis and evaluation of 1,2,4-oxadiazole derivatives as potential anti-inflammatory agents by inhibiting NF-κB signaling pathway in LPS-stimulated RAW 264.7 cells, Synthesis and evaluation of 1,2,4-oxadiazole derivatives as potential anti-inflammatory agents by inhibiting NF-κB signaling pathway in LPS-stimulated RAW 264.7 cells, select article Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome, Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome, select article 5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors, 5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors, select article Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists, select article Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes, Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-, select article New 30-norlupane derivatives through chemical-microbial semi-synthesis of betulinic acid and their neuroprotective effect, New 30-norlupane derivatives through chemical-microbial semi-synthesis of betulinic acid and their neuroprotective effect, select article Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands, Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands, select article Synthesis of 18F-labeled streptozotocin derivatives and an in-vivo kinetics study using positron emission tomography, select article Topical ‘dual-soft’ glucocorticoid receptor agonist for dermatology, Topical ‘dual-soft’ glucocorticoid receptor agonist for dermatology, select article Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp3 character and an exquisite selectivity profile, Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp, select article Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling, select article rkDNA–graphene oxide as a simple probe for the rapid detection of miRNA21, rkDNA–graphene oxide as a simple probe for the rapid detection of miRNA21, select article Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists, Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists, select article Study on antitumor activities of the chrysin-chromene-spirooxindole on Lewis lung carcinoma C57BL/6 mice in vivo, Study on antitumor activities of the chrysin-chromene-spirooxindole on Lewis lung carcinoma C57BL/6 mice, select article Development of phenylthiourea derivatives as allosteric inhibitors of pyoverdine maturation enzyme PvdP tyrosinase, Development of phenylthiourea derivatives as allosteric inhibitors of pyoverdine maturation enzyme PvdP tyrosinase, select article Synthesis of novel lignan-like compounds and their antimicrobial activity, Synthesis of novel lignan-like compounds and their antimicrobial activity, select article Identification of potent inhibitors of the sortilin-progranulin interaction, Identification of potent inhibitors of the sortilin-progranulin interaction, select article Graphical Abstract Contents Continued. Chem. Most notable are his development and application of the hetero Diels-Alder reaction to the syntheses of complex natural products, his development and applications of the cycloaddition reactions of cyclopropenone ketals, methodology based on the alkene addition reactions of acyl radicals, medium and large ring macrocyclization technology, and solution phase combinatorial chemistry methodology. Impact Factor: 2.572 ℹ Impact Factor: 2019: 2.572 The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. Help expand a public dataset of research that support the SDGs. In many cases he has undertaken an insightful study of the mechanisms by which key natural products exert their biological activity, which has led to unique insight into their mode of action. In a recent interview the winner commented on receiving the prize. Professor Boger is the co-author of over 600 scientific publications and was a founding editor of Bioorganic & Medicinal Chemistry Letters (1990-2015).